if you have a nvidia graphics card try an older driver. I had problems with the last driver in another game. i could go into the menu but if i wanted to play i had a CTD.
When I reinstalled the previous driver everything was ok again.
Alternatively, you can also have a look in your nvidia / ati system control if everything is right. (right graphics card, surround, physix, all effects such as AA off) then you should delete the shader folder of pr ...